Zhang Li-Ying, Zhou Jia-Hui, Xu Yun-He, Loh Teck-Peng
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China).
Chem Asian J. 2015 Apr;10(4):844-8. doi: 10.1002/asia.201403303. Epub 2015 Feb 5.
Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in reasonable yields and good enantioselectivities.
在温和的反应条件下，实现了铜催化4,4,4-三氟巴豆酸甲酯与脂肪族格氏试剂的对映选择性1,4-共轭加成反应，以构建一个连接有三氟甲基的不对称叔碳中心。所需产物能够以合理的产率和良好的对映选择性得到。
