Oldknow K J, MacRae V E, Farquharson C
Developmental BiologyThe Roslin Institute, Edinburgh, UK
Developmental BiologyThe Roslin Institute, Edinburgh, UK.
J Endocrinol. 2015 Apr;225(1):R1-19. doi: 10.1530/JOE-14-0584. Epub 2015 Feb 5.
Recent developments in endocrinology, made possible by the combination of mouse genetics, integrative physiology and clinical observations have resulted in rapid and unanticipated advances in the field of skeletal biology. Indeed, the skeleton, classically viewed as a structural scaffold necessary for mobility, and regulator of calcium-phosphorus homoeostasis and maintenance of the haematopoietic niche has now been identified as an important regulator of male fertility and whole-body glucose metabolism, in addition to the classical insulin target tissues. These seminal findings confirm bone to be a true endocrine organ. This review is intended to detail the key events commencing from the elucidation of osteocalcin (OC) in bone metabolism to identification of new and emerging candidates that may regulate energy metabolism independently of OC.
小鼠遗传学、整合生理学和临床观察相结合，推动了内分泌学的最新发展，在骨骼生物学领域取得了迅速且出人意料的进展。的确，传统上认为骨骼是运动所必需的结构支架，是钙磷稳态的调节者以及造血微环境的维持者，现在除了经典的胰岛素靶组织外，骨骼还被确定为男性生育能力和全身葡萄糖代谢的重要调节者。这些开创性的发现证实骨骼是一个真正的内分泌器官。本综述旨在详细阐述从骨代谢中骨钙素（OC）的阐明到鉴定可能独立于OC调节能量代谢的新出现候选物的关键事件。
