Karsenty G
Department of Genetics and Development, Columbia University, New York, New York 10032, USA.
Cold Spring Harb Symp Quant Biol. 2011;76:279-83. doi: 10.1101/sqb.2011.76.010934. Epub 2011 Aug 22.
A broadly held view of bone is that it is a tissue defined by its mechanical and scaffolding properties, whose interaction with other organs of the body is similar to that exerted by an armor protecting them. In the last 10 years, using mouse genetics, this view of bone as an assembly of inert calcified tubes has considerably evolved to a much more dynamic picture. It is now clear that the skeleton is not a simple target tissue for the hormones secreted by other organs, but it is an endocrine organ itself. Genetics and biochemical evidence have established that osteocalcin, an osteoblast-derived hormone, is an endocrine regulator of energy metabolism and male fertility. These novel hormonal connections between bone, energy metabolism, and reproduction underscore the concept of functional dependence in physiology and the importance of genetic approaches to identify novel endocrine regulations.
一种广泛持有的关于骨骼的观点是，它是一种由其机械和支架特性所定义的组织，其与身体其他器官的相互作用类似于盔甲对它们的保护作用。在过去十年中，利用小鼠遗传学，这种将骨骼视为惰性钙化管集合的观点已大幅演变为一幅更为动态的图景。现在很清楚，骨骼并非其他器官分泌的激素的简单靶组织，而是其本身就是一个内分泌器官。遗传学和生化证据已证实，成骨细胞衍生的激素骨钙素是能量代谢和男性生育能力的内分泌调节因子。骨骼、能量代谢和生殖之间这些新的激素联系强调了生理学中功能依赖性的概念以及基因方法在识别新的内分泌调节方面的重要性。
