Gupta Preeti, Cheung Carol Y, Saw Seang-Mei, Bhargava Mayuri, Tan Colin S, Tan Mellisa, Yang Adeline, Tey Frederick, Nah Gerard, Zhao Paul, Wong Tien Yin, Cheng Ching-Yu
Singapore Eye Research Institute and Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
Invest Ophthalmol Vis Sci. 2015 Feb 5;56(3):1475-81. doi: 10.1167/iovs.14-15742.
To describe the topography and predictors of peripapillary choroidal thickness (PPCT) in highly myopic eyes of young, healthy, Asian subjects.
A total of 870 young male subjects aged 21.63 ± 1.15 years were recruited from the Singapore military. Choroidal imaging was performed using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Peripapillary choroidal thickness was manually measured at eight locations around the optic disc.
We analyzed 448 subjects with high myopia (defined as spherical equivalent [SE] worse than -6.0 diopters [D]) and 116 with emmetropia (SE > -0.5 and < 0.5 D). The mean SE was -8.52 ± 1.20 D for the high-myopic group, and 0.11 ± 0.24 D for the emmetropic group. The mean peripapillary choroid was significantly thinner (142.62 ± 43.84 μm) in high myopes compared with emmetropes (181.90 ± 46.43 μm, P < 0.001). Likewise, PPCT showed further decrease with increase in degree of myopic refractive error. Distribution of PPCT showed a markedly different pattern in high-myopic eyes (thickest superiorly) and emmetropic eyes (thickest temporally). However, peripapillary choroid in both the groups was thinnest at the inferior location. Among the ocular factors studied, axial length, IOP, presence of posterior staphyloma, and chorioretinal atrophy were the factors significantly associated with PPCT.
Highly myopic eyes have significantly thinner peripapillary choroid and showed different distribution of thickness, compared with emmetropes. Axial length, IOP, and presence of posterior staphyloma and chorioretinal atrophy significantly influence PPCT and should be taken into consideration during clinical interpretation of PPCT measurement.
描述年轻、健康亚洲受试者高度近视眼中视乳头周围脉络膜厚度（PPCT）的形态及预测因素。
从新加坡军队招募了870名年龄为21.63±1.15岁的年轻男性受试者。使用增强深度成像（EDI）光谱域光学相干断层扫描（SD-OCT）进行脉络膜成像。在视盘周围的八个位置手动测量视乳头周围脉络膜厚度。
我们分析了448名高度近视患者（定义为等效球镜度[SE]低于-6.0屈光度[D]）和116名正视眼患者（SE＞-0.5且＜0.5 D）。高度近视组的平均SE为-8.52±1.20 D，正视组为0.11±0.24 D。与正视眼（181.90±46.43μm，P＜0.001）相比，高度近视患者的平均视乳头周围脉络膜明显更薄（142.62±43.84μm）。同样，PPCT随着近视屈光不正度数的增加而进一步降低。PPCT的分布在高度近视眼中（上方最厚）和正视眼中（颞侧最厚）显示出明显不同的模式。然而，两组的视乳头周围脉络膜在下侧位置最薄。在所研究的眼部因素中，眼轴长度、眼压、后巩膜葡萄肿的存在以及脉络膜视网膜萎缩是与PPCT显著相关的因素。
与正视眼相比，高度近视眼中视乳头周围脉络膜明显更薄，且厚度分布不同。眼轴长度、眼压、后巩膜葡萄肿和脉络膜视网膜萎缩的存在显著影响PPCT，在对PPCT测量进行临床解读时应予以考虑。
