Kemeny M E, Cohen F, Zegans L S, Conant M A
Department of Psychiatry, University of California, Los Angeles.
Psychosom Med. 1989 Mar-Apr;51(2):195-208. doi: 10.1097/00006842-198903000-00008.
The relationships among stressful life experience, mood, helper-inducer (CD4+) and suppressor-cytotoxic (CD8+) T cells and genital herpes simplex virus (HSV) recurrence were investigated prospectively in 36 patients with recurrent HSV. The following factors were measured monthly for six months: stressful life experience (including current acute and ongoing stressors, residual effects of previous stressors, and anticipation of future stressors), negative mood, health behaviors, other possible HSV triggers, HSV recurrences, and the proportion of CD4+ and CD8+ cells (in half the sample). Results averaging monthly scores over the six-month study period indicated that: 1) subjects with high levels of stressful experience had a lower proportion of both CD4+ and CD8+ cells, 2) subjects with high levels of depressive mood, anxiety, or hostility had a lower proportion of CD8+ cells, and 3) subjects with high levels of depressive mood who did not report many symptoms of other infections had a higher rate of HSV recurrence. A model is proposed linking depressive mood, CD8+ cells, and HSV recurrence.
对36例复发性单纯疱疹病毒（HSV）感染患者进行前瞻性研究，以调查应激性生活经历、情绪、辅助诱导型（CD4 +）和抑制细胞毒性型（CD8 +）T细胞与生殖器HSV复发之间的关系。在六个月的时间里，每月测量以下因素：应激性生活经历（包括当前的急性和持续性应激源、先前应激源的残留影响以及对未来应激源的预期）、负面情绪、健康行为、其他可能的HSV触发因素、HSV复发情况以及CD4 +和CD8 +细胞的比例（在一半的样本中）。对六个月研究期内的每月平均得分进行分析，结果表明：1）应激经历水平高的受试者CD4 +和CD8 +细胞的比例较低；2）抑郁情绪、焦虑或敌意水平高的受试者CD8 +细胞的比例较低；3）未报告许多其他感染症状但抑郁情绪水平高的受试者HSV复发率较高。提出了一个将抑郁情绪、CD8 +细胞和HSV复发联系起来的模型。
