Störkel S, Steart P V, Drenckhahn D, Thoenes W
Department of Pathology, University of Mainz, Federal Republic of Germany.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;56(4):237-45. doi: 10.1007/BF02890022.
In the present study we have examined ten cases of the chromophobe type renal cell carcinoma. This type of tumor is distinguished from the other carcinomas of the kidney with light cytoplasm (formerly called "hypernephroid") by (a) a positive Hale's iron colloid stain of the cytoplasm, (b) the occurrence of numerous invaginated vesicles within the cytoplasm that resemble the invaginated vesicles of intercalated cells of the collecting duct system, and (c) a positive immunoreaction of both the plasma membrane and the cytoplasm with antibodies to the epithelial membrane antigen (EMA) and carbonic anhydrase C (CAC), respectively. Unlike oncocytomas, which also express CAC and EMA, the chromophobe renal cell carcinoma does not express the erythrocyte anion exchanger band 3. These findings strongly indicate that chromophobe renal cell carcinomas as well as oncocytomas of the kidney are histogenetically related to the two populations of intercalated cells of the collecting duct system. Thus, both tumors represent examples of renal tumors which disprove the broadly accepted hypothesis that all epithelial tumors of the kidney are histogenetically related to the proximal tubule.
在本研究中，我们检查了10例嫌色细胞型肾细胞癌。这种肿瘤与其他具有淡染细胞质的肾癌（以前称为“肾上腺样瘤”）的区别在于：(a) 细胞质的Hale氏铁胶体染色呈阳性；(b) 细胞质内出现许多内陷小泡，类似于集合管系统闰细胞的内陷小泡；(c) 质膜和细胞质分别与上皮膜抗原（EMA）抗体和碳酸酐酶C（CAC）抗体发生阳性免疫反应。与同样表达CAC和EMA的嗜酸性细胞瘤不同，嫌色肾细胞癌不表达红细胞阴离子交换蛋白带3。这些发现有力地表明，嫌色肾细胞癌以及肾嗜酸性细胞瘤在组织发生学上与集合管系统的两种闰细胞群相关。因此，这两种肿瘤均代表了肾肿瘤的实例，它们反驳了广泛接受的假说，即所有肾上皮性肿瘤在组织发生学上均与近端小管相关。
