Störkel S, Pannen B, Thoenes W, Steart P V, Wagner S, Drenckhahn D
Department of Pathology, University of Mainz, Federal Republic of Germany.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;56(3):185-9. doi: 10.1007/BF02890016.
Renal oncocytoma is a distinct type of epithelial tumor said to arise from the collecting duct system. Here we show that in nine of ten oncocytomas the tumor cells expressed an analog of the erythrocyte anion exchanger band 3. In the normal kidney band 3 is confined to the basolateral surface of the majority of intercalated cells which comprise up to 50% of the cortical collecting duct epithelium. Carbonic anhydrase c is another protein abundant in intercalated cells, and this was also expressed in six of the ten oncocytomas investigated. Immunoreactivity specific for band 3 and carbonic anhydrase c was not detected in any of the 20 renal cell carcinomas examined. At favourable section planes direct transitions between normal collecting ducts and oncocytic tubules were observed. These findings suggest that oncocytomas may develop from intercalated cells of the collecting duct epithelium.
肾嗜酸细胞瘤是一种独特的上皮性肿瘤，据说起源于集合管系统。我们在此表明，在十例嗜酸细胞瘤中有九例的肿瘤细胞表达了红细胞阴离子交换蛋白带3的类似物。在正常肾脏中，带3局限于大多数闰细胞的基底外侧表面，这些闰细胞占皮质集合管上皮细胞的比例高达50%。碳酸酐酶c是闰细胞中另一种丰富的蛋白质，在所研究的十例嗜酸细胞瘤中有六例也表达了该蛋白。在检查的20例肾细胞癌中均未检测到针对带3和碳酸酐酶c的免疫反应性。在合适的切片平面上，观察到正常集合管与嗜酸细胞小管之间的直接过渡。这些发现表明，嗜酸细胞瘤可能起源于集合管上皮的闰细胞。
