Eikelenboom P, Hack C E, Rozemuller J M, Stam F C
Department of Psychiatry, Medical Faculty, Free University, Amsterdam, The Netherlands.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;56(4):259-62. doi: 10.1007/BF02890024.
Amyloid plaques in Alzheimer's dementia contain complement factors C1q, C4 and C3. In the present study we demonstrate complement activation in amyloid plaques using immunoenzymatical techniques and specific antibodies against subunits of individual complement components and activated complement products. Amyloid plaques contain C1q and activated C3 fragments (C3c and C3d, g) but no C1s and C3a. These findings demonstrate that the complement components are not passively bound to the amyloid plaque structures but are the result of an activation process. The role of complement activation in the genesis of senile plaques is discussed.
阿尔茨海默病性痴呆中的淀粉样斑块含有补体因子C1q、C4和C3。在本研究中，我们使用免疫酶技术以及针对各个补体成分亚基和活化补体产物的特异性抗体，证明了淀粉样斑块中的补体激活。淀粉样斑块含有C1q和活化的C3片段（C3c和C3d、g），但不含C1s和C3a。这些发现表明，补体成分并非被动地结合于淀粉样斑块结构，而是激活过程的结果。本文讨论了补体激活在老年斑形成中的作用。
