Eikelenboom P, Stam F C
Acta Neuropathol. 1982;57(2-3):239-42. doi: 10.1007/BF00685397.
Immunoperoxidase techniques were used to obtain information about the possible presence of serum factors in senile plaques. We found only in plaques consisting of an amyloid core surrounded by a corona of degenerating neurites small amounts of IgG and light chains (kappa and lambda). These immunoglobulins were principally localized in the corona and not in the central amyloid core. Further it was found that all plaques contain the complement factors C1q, C3b, C3c, C3d and C4. Senile plaques lacked C5, C3 pro-activator and properdin. The possible significance of these findings in the genesis of the senile plaques and amyloid formation is discussed.
采用免疫过氧化物酶技术来获取有关老年斑中可能存在血清因子的信息。我们仅在由淀粉样蛋白核心和围绕其的变性神经突晕组成的斑块中发现了少量的IgG和轻链（κ链和λ链）。这些免疫球蛋白主要定位于晕中，而非中央淀粉样蛋白核心。此外，还发现所有斑块都含有补体因子C1q、C3b、C3c、C3d和C4。老年斑缺乏C5、C3前激活物和备解素。本文讨论了这些发现对老年斑形成和淀粉样蛋白形成的可能意义。
