Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Immunobiology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Science. 2015 Feb 6;347(6222):667-72. doi: 10.1126/science.aaa1300.
The layer of macrophages at the subcapsular sinus (SCS) captures pathogens entering the lymph node, preventing their global dissemination and triggering an immune response. However, how infection affects SCS macrophages remains largely unexplored. Here we show that infection and inflammation disrupt the organization of SCS macrophages in a manner that involves the migration of mature dendritic cells to the lymph node. This disrupted organization reduces the capacity of SCS macrophages to retain and present antigen in a subsequent secondary infection, resulting in diminished B cell responses. Thus, the SCS macrophage layer may act as a sensor or valve during infection to temporarily shut down the lymph node to further antigenic challenge. This shutdown may increase an organism's susceptibility to secondary infections.
被膜下窦（SCS）中的巨噬细胞层捕获进入淋巴结的病原体，防止其全身传播并引发免疫反应。然而，感染如何影响 SCS 巨噬细胞在很大程度上仍未得到探索。在这里，我们表明感染和炎症以一种涉及成熟树突状细胞迁移到淋巴结的方式破坏 SCS 巨噬细胞的组织。这种组织的破坏降低了 SCS 巨噬细胞在随后的二次感染中保留和呈递抗原的能力，导致 B 细胞反应减弱。因此，SCS 巨噬细胞层在感染期间可能充当传感器或阀门，暂时关闭淋巴结以防止进一步的抗原挑战。这种关闭可能会增加生物体对二次感染的易感性。
