Susanne V. Koch, MD, PhD, Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region and Institute of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; Janne T. Larsen, MSc, National Center for Register-based Research, School of Business and Social Sciences, University of Aarhus, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPsych, Department of Biomedicine, Faculty of Health, Aarhus University, Denmark; Svend E. Mouridsen, MScPsych, Mette Bentz, MScPsych, Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region, Denmark; Liselotte Petersen, MSc, PhD, National Center for Register-based Research, School of Business and Social Sciences, University of Aarhus, Aarhus, iPsych, Department of Biomedicine, Faculty of Health, Aarhus University, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Cynthia Bulik, PhD, FAED, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA, and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Preben B. Mortensen, MD, DMSci, National Center for Register-based Research, School of Business and Social Sciences, University of Aarhus, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPsych, Department of Biomedicine, Faculty of Health, Aarhus University, Denmark; Kerstin J. Plessen, MD, PhD, Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region and Institute of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Br J Psychiatry. 2015 May;206(5):401-7. doi: 10.1192/bjp.bp.114.153221. Epub 2015 Feb 5.
Clinical and population-based studies report increased prevalence of autism spectrum disorders (ASD) in individuals with anorexia nervosa and in their relatives. No nationwide study has yet been published on co-occurrence of these disorders.
To investigate comorbidity of ASD in individuals with anorexia nervosa, and aggregation of ASD and anorexia nervosa in their relatives.
In Danish registers we identified all individuals born in 1981-2008, their parents, and full and half siblings, and linked them to data on hospital admissions for psychiatric disorders.
Risk of comorbidity of ASD in probands with anorexia nervosa and aggregation of ASD in families of anorexia nervosa probands were increased. However, the risk of comorbid and familial ASD did not differ significantly from comorbid and familial major depression or any psychiatric disorder in anorexia nervosa probands.
We confirm aggregation of ASD in probands with anorexia nervosa and in their relatives; however, the relationship between anorexia nervosa and ASD appears to be non-specific.
临床和基于人群的研究报告称，厌食症患者及其亲属的自闭症谱系障碍（ASD）患病率增加。尚未发表关于这些疾病同时发生的全国性研究。
调查厌食症患者中 ASD 的共病情况，以及 ASD 和厌食症在其亲属中的聚集情况。
在丹麦登记处，我们确定了所有 1981 年至 2008 年出生的个体、他们的父母以及全同胞和半同胞，并将他们与精神疾病住院数据相关联。
厌食症患者 ASD 共病的风险和厌食症患者家庭中 ASD 的聚集增加。然而，ASD 共病和家族性 ASD 的风险与厌食症患者中并发和家族性重度抑郁症或任何精神障碍没有显著差异。
我们证实了厌食症患者中 ASD 的聚集和他们的亲属；然而，厌食症和 ASD 之间的关系似乎是非特异性的。
