Ozuguz Pinar, Kacar Seval Dogruk, Manav Vildan, Karaca Semsettin, Aktepe Fatma, Ulu Sena
Afyon Kocatepe University Department of Dermatology, Afyon, Turkey.
Department of Pathology, Afyon Kocatepe University Dermatology, Afyon, Turkey.
Indian J Dermatol. 2015 Jan-Feb;60(1):105. doi: 10.4103/0019-5154.147866.
Behçet's disease (BD), first described by Hulusi Behcet, is a multisystemic disease characterized by recurrent oral and genital ulcerations, ocular and cutaneous lesions, arthritis and vascular disease. Pyoderma gangrenosum (PG) is a rare, chronic, sterile pustular and progressive ulcerative process of unknown cause; sometimes can participate in the differential diagnosis of Behcet's ulceration. A 33-year-old woman complained a severe genital ulcer. She had a purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm. A punch biopsy at ulcer margin showed that the lymphocytic panniculitis was extending to the subcutaneous fat tissue without fibrin deposition or necrotic changes in the vessel wall. Based on the clinical and histological findings, she was diagnosed as genital ulcerative PG, which occurred during the exacerbation of BD.
白塞病（BD）由胡卢西·白塞首次描述，是一种多系统疾病，其特征为复发性口腔和生殖器溃疡、眼部及皮肤病变、关节炎和血管疾病。坏疽性脓皮病（PG）是一种罕见的、慢性的、无菌性脓疱性且进行性溃疡性疾病，病因不明；有时可参与白塞病溃疡的鉴别诊断。一名33岁女性主诉严重的生殖器溃疡。她小阴唇右侧有一个脓性渗出且有臭味的溃疡，大小为5 - 8厘米。溃疡边缘的组织活检显示淋巴细胞性脂膜炎延伸至皮下脂肪组织，血管壁无纤维蛋白沉积或坏死改变。根据临床和组织学检查结果，她被诊断为生殖器溃疡性PG，发生于白塞病病情加重期间。
