利妥昔单抗治疗系统性红斑狼疮中类固醇抵抗性自身免疫性血小板减少症。
Steroid-resistant autoimmune thrombocytopenia in systemic lupus erythematosus treated with rituximab.
作者信息
Sardesai Vasudha V, Sardesai Vidyadhar R, Agarwal Trupti D
机构信息
Department of Medicine, Bharati Vidyapeeth University Medical College and Hospital, Pune, Maharashtra, India.
Department of Dermatology, Venereology and Leprosy, Bharati Vidyapeeth University Medical College and Hospital, Pune, Maharashtra, India.
出版信息
Indian J Dermatol. 2015 Jan-Feb;60(1):106. doi: 10.4103/0019-5154.147874.
Systemic Lupus Erythematosus (SLE) is a multisystem disorder characterized by production of numerous autoantibodies, some of which have pathogenic consequences and result in considerable morbidity. Herein, we present a case of 48-year-old female with SLE having autoimmune hemolytic anemia, autoimmune thrombocytopenia, renal involvement, and recurrent flares of skin manifestations. She did not respond to the conventional therapy and was controlled and treated with Rituximab, a chimeric, monoclonal antiCD20 antibody, which specifically depletes B lymphocytes.
系统性红斑狼疮（SLE）是一种多系统疾病，其特征是产生多种自身抗体，其中一些具有致病后果并导致相当高的发病率。在此，我们报告一例48岁患有SLE的女性病例，该患者伴有自身免疫性溶血性贫血、自身免疫性血小板减少症、肾脏受累以及皮肤表现反复发作。她对传统治疗无反应，随后使用利妥昔单抗进行控制和治疗，利妥昔单抗是一种嵌合单克隆抗CD20抗体，可特异性清除B淋巴细胞。
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