Denda A, Tsutsumi M, Tsujiuchi T, Eimoto H, Konishi Y, Sato S
Department of Oncological Pathology, Nara Medical College, Japan.
Cancer Lett. 1989 Apr;45(1):21-6. doi: 10.1016/0304-3835(89)90031-1.
In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was observed with all the doses of 1-NP (1000, 500, 250 and 100 mg/kg body wt) used in the present experiment after 6 repeated intragastric (i.g.) intubations when accompanied by partial hepatectomy (PH) performed midway, but not after a single i.g. 1000 mg/kg body wt intubation plus PH. The potential for induction of foci by 1-NP, however, was far less than that by benzo[a]pyrene (B[a]P). The results thus suggested a weak but substantial initiation activity for 1-NP in the rat liver when given orally, particularly with repeated doses.
在本研究中，检测了普遍存在的环境污染物1-硝基芘（1-NP）经口给予F344大鼠时，是否能诱发γ-谷氨酰转肽酶（GGT）阳性病灶，这是肝癌发生过程中出现的早期病变。在本实验中，当在中途进行部分肝切除术（PH）的情况下，经6次重复灌胃（i.g.）给予所有剂量的1-NP（1000、500、250和100mg/kg体重）后，观察到GGT阳性病灶有显著诱导，但在单次经口给予1000mg/kg体重并进行PH后未观察到。然而，1-NP诱导病灶的潜力远小于苯并[a]芘（B[a]P）。因此，结果表明1-NP经口给予大鼠肝脏时具有微弱但显著的启动活性，尤其是重复给药时。
