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本文引用的文献

1
Methylglyoxal formation in rat liver cells.大鼠肝细胞中甲基乙二醛的形成。
J Biol Chem. 1980 Mar 10;255(5):2046-50.
2
Reliable stereological method for estimating the number of microscopic hepatocellular foci from their transections.一种通过肝细胞微观病灶横断面来估计其数量的可靠体视学方法。
Cancer Res. 1983 Mar;43(3):1261-8.
3
Mutagenicity of methylglyoxal in coffee.咖啡中甲基乙二醛的致突变性。
Gan. 1982 Oct;73(5):681-3.
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Mutagens-carcinogens in foods.
Cancer Res. 1983 May;43(5 Suppl):2415s-2421s.
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Survey of various chemicals for initiating and promoting activities in a short-term in vivo system based on generation of hyperplastic liver nodules in rats.基于大鼠肝脏增生性结节生成的短期体内系统中各种化学物质启动和促进活性的研究。
Carcinogenesis. 1983;4(4):381-6. doi: 10.1093/carcin/4.4.381.
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The sequential analysis of cancer development.癌症发展的序贯分析。
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7
Phenotypic diversity as an early property of putative preneoplastic hepatocyte populations in liver carcinogenesis.表型多样性作为肝癌发生过程中假定的癌前肝细胞群体的早期特性。
Cancer Res. 1980 Mar;40(3):725-33.
8
Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity.γ-谷氨酰转肽酶活性的组织化学和超微结构显示
J Histochem Cytochem. 1969 Aug;17(8):517-26. doi: 10.1177/17.8.517.
9
Nonenzymic, polyvalent anion-catalyzed formation of methylglyoxal as an explanation of its presence in physiological systems.非酶促、多价阴离子催化甲基乙二醛的形成，以此解释其在生理系统中的存在。
J Biol Chem. 1968 May 25;243(10):2718-24.
10
Induction of sister-chromatid exchanges in Chinese hamster ovary cells by the biotic ketoaldehyde methylglyoxal.生物性酮醛甲基乙二醛在中国仓鼠卵巢细胞中诱导姐妹染色单体交换
Mutat Res. 1985 Nov;144(3):189-91. doi: 10.1016/0165-7992(85)90138-1.

甲基乙二醛对大鼠肝脏中γ-谷氨酰转肽酶阳性病灶的诱导和促进作用

Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal.

作者信息

Martelli A, Ghia M, Mereto E, Marinari U M, Brambilla G

机构信息

Institute of Pharmacology, University of Genoa, Italy.

出版信息

Jpn J Cancer Res. 1988 Jun;79(6):666-9. doi: 10.1111/j.1349-7006.1988.tb02218.x.

DOI:10.1111/j.1349-7006.1988.tb02218.x
PMID:2900825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917568/
Abstract

The effect of pre-(initiation) and post-(promotion) administration of methylglyoxal (MG) on the induction of gamma-glutamyltranspeptidase (GGT)-positive foci in the liver of F344 male rats was investigated. GGT-positive foci were produced in dose-related amounts by 0.05 and 0.2% MG in drinking water, either when administered to uninitiated rats or when given in the promotion phase.

摘要

研究了甲基乙二醛（MG）在启动前和促进后给药对F344雄性大鼠肝脏中γ-谷氨酰转肽酶（GGT）阳性灶诱导的影响。当给予未启动的大鼠或在促进阶段给予时，饮用水中0.05%和0.2%的MG均以剂量相关的量产生GGT阳性灶。