甲基乙二醛对大鼠肝脏中γ-谷氨酰转肽酶阳性病灶的诱导和促进作用
Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal.
作者信息
Martelli A, Ghia M, Mereto E, Marinari U M, Brambilla G
机构信息
Institute of Pharmacology, University of Genoa, Italy.
出版信息
Jpn J Cancer Res. 1988 Jun;79(6):666-9. doi: 10.1111/j.1349-7006.1988.tb02218.x.
Abstract
The effect of pre-(initiation) and post-(promotion) administration of methylglyoxal (MG) on the induction of gamma-glutamyltranspeptidase (GGT)-positive foci in the liver of F344 male rats was investigated. GGT-positive foci were produced in dose-related amounts by 0.05 and 0.2% MG in drinking water, either when administered to uninitiated rats or when given in the promotion phase.
摘要
研究了甲基乙二醛（MG）在启动前和促进后给药对F344雄性大鼠肝脏中γ-谷氨酰转肽酶（GGT）阳性灶诱导的影响。当给予未启动的大鼠或在促进阶段给予时，饮用水中0.05%和0.2%的MG均以剂量相关的量产生GGT阳性灶。
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