Al-Rayahi Izzat A M, Sanyi Raghad H H
Department of Infection, Immunity and Inflammation, College of Medicine, Biological Sciences and Psychology, University of Leicester , Leicester , UK ; The Ministry of Higher Education , Baghdad , Iraq.
Front Immunol. 2015 Jan 22;6:2. doi: 10.3389/fimmu.2015.00002. eCollection 2015.
Antimicrobial peptides (AMPs) represent a group of small (6-100 amino acids), biologically active molecules, which are produced by plants, mammals, and microorganisms (1). An important element of the innate immune response, AMP, possesses potent antibiotic, antifungal, and antiviral activities. Furthermore, AMP may be involved in a number of other processes such as angiogenesis and modulation of the immune response such as stimulation of chemokines and chemotaxis of leukocytes. AMPs have been proposed as alternative therapies for infectious diseases. AMP may also exert cytotoxic activity against tumor cells. Further understanding of the biological function of these peptides during tumor development and progression may aid in the development of novel anti-tumor therapies with refined application of innate molecules. AMP and complement have distinct roles to play in shaping the microenvironment (Table 1). Components of the complement system are integral contributors in responding to infection and sterile inflammation. Moreover, complement plays a role in the trafficking of cells in the tumor microenvironment, and thereby possibly in the immune response to cancer. This article will try to outline characteristics of AMP and complement in mobilization and recruitment of cells in tumor microenvironment.
抗菌肽（AMPs）是一类由植物、哺乳动物和微生物产生的小分子（6 - 100个氨基酸）生物活性分子（1）。作为先天性免疫反应的一个重要元素，抗菌肽具有强大的抗菌、抗真菌和抗病毒活性。此外，抗菌肽可能参与许多其他过程，如血管生成和免疫反应的调节，如刺激趋化因子和白细胞的趋化作用。抗菌肽已被提议作为传染病的替代疗法。抗菌肽也可能对肿瘤细胞发挥细胞毒性作用。进一步了解这些肽在肿瘤发生和发展过程中的生物学功能，可能有助于开发出更精确应用先天性分子的新型抗肿瘤疗法。抗菌肽和补体在塑造微环境中发挥着不同的作用（表1）。补体系统的成分是应对感染和无菌性炎症的重要贡献者。此外，补体在肿瘤微环境中的细胞运输中发挥作用，从而可能在对癌症的免疫反应中发挥作用。本文将试图概述抗菌肽和补体在肿瘤微环境中细胞动员和募集方面的特征。
