Spring B, Chiodo J, Harden M, Bourgeois M J, Mason J D, Lutherer L
Department of Psychology, UHS, Chicago Medical School, IL 60064.
J Clin Psychiatry. 1989 May;50 Suppl:27-33; discussion 34.
The authors studied whether the fatiguing effects of eating lunch are greater for carbohydrate-rich meals than for other meals, and related the time course of behavioral change to plasma glucose, insulin, and amino acids. On different occasions, in counterbalanced order, normal women (N = 7) fasted overnight, ate a standard breakfast, and at lunch either continued to fast or ate a high-carbohydrate, low-protein meal; a hedonically similar meal containing both carbohydrate and protein; or a high-protein, low-carbohydrate meal. Meals were isocaloric and equated for fat content. Only the carbohydrate meal significantly increased fatigue, which could not be attributed to hypoglycemia because plasma glucose remained elevated. Fatigue began approximately, when the carbohydrate meal elevated the plasma tryptophan ratio but ended even though the ratio remained elevated. Fatigue after a high-carbohydrate lunch could not be explained by reactive hypoglycemia or sweet taste, and could partially be explained by the hypothesis that fatigue parallels an elevation of the tryptophan ratio.
作者研究了午餐时进食富含碳水化合物的餐食是否比其他餐食产生更大的疲劳效应，并将行为变化的时间进程与血浆葡萄糖、胰岛素和氨基酸联系起来。在不同的场合，按照平衡顺序，正常女性（N = 7）隔夜禁食，吃标准早餐，午餐时要么继续禁食，要么吃高碳水化合物、低蛋白餐；一顿含有碳水化合物和蛋白质且享乐性相似的餐食；或者高蛋白、低碳水化合物餐。餐食热量相等且脂肪含量相同。只有碳水化合物餐显著增加了疲劳感，这不能归因于低血糖，因为血浆葡萄糖仍处于升高状态。疲劳大约在碳水化合物餐提高血浆色氨酸比值时开始，但即使该比值仍保持升高，疲劳感也会结束。高碳水化合物午餐后的疲劳不能用反应性低血糖或甜味来解释，部分可以用疲劳与色氨酸比值升高平行的假说来解释。
