Shearer James, Tie Hiong, Byford Sarah
Centre for the Economics of Mental and Physical Health, Institute of Psychiatry, King's College London, London, UK.
Drug Alcohol Rev. 2015 May;34(3):289-98. doi: 10.1111/dar.12240. Epub 2015 Feb 8.
UK clinical guidelines published in 2007 recommended contingency management (CM) as an adjunct to opiate substitution therapy. However, CM has not been adopted in the UK despite evidence of clinical effectiveness. Evidence for the cost-effectiveness of CM is less clear and will need to be explored if CM is to be adopted by national health systems in countries such as the UK.
Systematic review and descriptive synthesis of published economic evaluations.
The review identified nine published studies that could be classified as economic evaluations. These were all based within US treatment settings, and five were conducted by the same group of authors. All studies found that the addition of CM to usual care increased both costs and effects (commonly drug abstinence or medication adherence).
This review confirms that the existing evidence base for cost-effectiveness has limited generalisability beyond the original research clinical settings and populations.
The data were not sufficiently strong to make any conclusion about the cost-effectiveness of CM. More relevant and comprehensive evidence for cost-effectiveness than currently exists is needed.
2007年发布的英国临床指南推荐将应急管理(CM)作为阿片类药物替代疗法的辅助手段。然而,尽管有临床有效性的证据,但CM在英国尚未得到采用。CM成本效益的证据尚不明确,如果英国等国家的国家卫生系统要采用CM,则需要对此进行探讨。
对已发表的经济评估进行系统评价和描述性综合分析。
该评价确定了九项可归类为经济评估的已发表研究。这些研究均以美国的治疗环境为基础,其中五项由同一组作者进行。所有研究均发现,在常规护理中增加CM会增加成本和效果(通常是药物戒断或药物依从性)。
该评价证实,现有的成本效益证据基础在超出原始研究临床环境和人群之外的可推广性有限。
数据不够有力,无法就CM的成本效益得出任何结论。需要比目前更相关、更全面的成本效益证据。