University of Colorado Denver, Rocky Mountain Lions Eye Institute, Aurora, CO, USA; University of Colorado Denver, Department of Ophthalmology, Denver, CO, USA.
University of Colorado Denver, Department of Physics, Denver, CO, USA.
Comput Biol Med. 2015 Mar;58:154-62. doi: 10.1016/j.compbiomed.2014.12.021. Epub 2015 Jan 5.
This paper uses computer modeling to estimate the progressive decline in oxygenation that occurs in the human diabetic retina after years of slowly progressive ischemic insult. An established model combines diffusion, saturable consumption, and blood capillary sources to determine the oxygen distribution across the retina. Incorporating long-term degradation of blood supply from the retinal capillaries into the model yields insight into the effects of progressive ischemia associated with prolonged hyperglycemia, suggesting time-scales over which therapeutic mitigation could have beneficial effect. A new extension of the model for oxygen distribution introduces a feedback mechanism for vasodilation and its potential to prolong healthy retinal function.
本文通过计算机建模来估计人类糖尿病视网膜在多年缓慢进行性缺血损伤后，其氧合作用逐渐下降的情况。一个成熟的模型将扩散、饱和消耗和毛细血管血液源结合起来，以确定视网膜的氧气分布。将视网膜毛细血管长期血液供应退化纳入模型中，可以深入了解与长期高血糖相关的进行性缺血的影响，表明治疗缓解可能产生有益效果的时间范围。该模型的氧分布新扩展引入了血管扩张的反馈机制及其延长健康视网膜功能的潜力。
