Department of Psychiatry, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.
Department of Psychiatry, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.
Psychiatry Res. 2015 Mar 30;226(1):273-6. doi: 10.1016/j.psychres.2014.12.061. Epub 2015 Jan 13.
This study investigates the possible relationship between pathological gambling (PG) and potential spectrum disorders including the DSM-IV impulse control disorders (intermittent explosive disorder, kleptomania, pyromania, trichotillomania) and several non-DSM disorders (compulsive buying disorder, compulsive sexual behavior, Internet addiction). PG probands, controls, and their first-degree relatives were assessed with instruments of known reliability. Detailed family history information was collected on relatives who were deceased or unavailable. Best estimate diagnoses were assigned blind to family status. The results were analyzed using logistic regression by the method of generalized estimating equations. The sample included 95 probands with PG, 91 controls, and 1075 first-degree relatives (537 PG, 538 controls). Compulsive buying disorder and having "any spectrum disorder" were more frequent in the PG probands and their first-degree relatives vs. controls and their relatives. Spectrum disorders were significantly more prevalent among PG relatives compared to control relatives (adjusted OR=8.37), though much of this difference was attributable to the contribution from compulsive buying disorder. We conclude that compulsive buying disorder is likely part of familial PG spectrum.
本研究调查了病理性赌博 (PG) 与潜在谱障碍之间的可能关系，包括 DSM-IV 冲动控制障碍（间歇性爆发障碍、偷窃癖、纵火狂、拔毛癖）和几种非 DSM 障碍（强迫性购买障碍、强迫性行为、网络成瘾）。PG 先证者、对照者及其一级亲属接受了具有已知可靠性的工具评估。对已故或无法获得的亲属进行了详细的家族史信息收集。根据家族状况进行盲法最佳估计诊断。使用广义估计方程的逻辑回归方法对结果进行分析。样本包括 95 名患有 PG 的先证者、91 名对照者和 1075 名一级亲属（537 名 PG、538 名对照者）。强迫性购买障碍和“任何谱障碍”在 PG 先证者及其一级亲属中比对照者及其亲属更为常见。与对照亲属相比，PG 亲属的谱障碍明显更为普遍（调整后的 OR=8.37），尽管这种差异很大程度上归因于强迫性购买障碍的贡献。我们得出结论，强迫性购买障碍可能是家族性 PG 谱的一部分。
