Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark.
Saint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, Missouri.
J Am Coll Cardiol. 2015 Feb 10;65(5):411-9. doi: 10.1016/j.jacc.2014.11.023.
People who are physically active have at least a 30% lower risk of death during follow-up compared with those who are inactive. However, the ideal dose of exercise for improving longevity is uncertain.
The aim of this study was to investigate the association between jogging and long-term, all-cause mortality by focusing specifically on the effects of pace, quantity, and frequency of jogging.
As part of the Copenhagen City Heart Study, 1,098 healthy joggers and 3,950 healthy nonjoggers have been prospectively followed up since 2001. Cox proportional hazards regression analysis was performed with age as the underlying time scale and delayed entry.
Compared with sedentary nonjoggers, 1 to 2.4 h of jogging per week was associated with the lowest mortality (multivariable hazard ratio [HR]: 0.29; 95% confidence interval [CI]: 0.11 to 0.80). The optimal frequency of jogging was 2 to 3 times per week (HR: 0.32; 95% CI: 0.15 to 0.69) or ≤1 time per week (HR: 0.29; 95% CI: 0.12 to 0.72). The optimal pace was slow (HR: 0.51; 95% CI: 0.24 to 1.10) or average (HR: 0.38; 95% CI: 0.22 to 0.66). The joggers were divided into light, moderate, and strenuous joggers. The lowest HR for mortality was found in light joggers (HR: 0.22; 95% CI: 0.10 to 0.47), followed by moderate joggers (HR: 0.66; 95% CI: 0.32 to 1.38) and strenuous joggers (HR: 1.97; 95% CI: 0.48 to 8.14).
The findings suggest a U-shaped association between all-cause mortality and dose of jogging as calibrated by pace, quantity, and frequency of jogging. Light and moderate joggers have lower mortality than sedentary nonjoggers, whereas strenuous joggers have a mortality rate not statistically different from that of the sedentary group.
与不运动的人相比，有规律运动的人在随访期间的死亡率至少低 30%。然而，目前尚不确定提高寿命的理想运动剂量。
本研究旨在通过专门关注慢跑的速度、数量和频率的影响，探讨慢跑与长期全因死亡率之间的关系。
作为哥本哈根城市心脏研究的一部分，自 2001 年以来，对 1098 名健康慢跑者和 3950 名健康非慢跑者进行了前瞻性随访。使用年龄作为潜在时间尺度和延迟进入进行 Cox 比例风险回归分析。
与久坐不动的非慢跑者相比，每周慢跑 1 至 2.4 小时与最低死亡率相关（多变量风险比[HR]：0.29；95%置信区间[CI]：0.11 至 0.80）。慢跑的最佳频率为每周 2 至 3 次（HR：0.32；95%CI：0.15 至 0.69）或每周 1 次以下（HR：0.29；95%CI：0.12 至 0.72）。最佳速度为慢（HR：0.51；95%CI：0.24 至 1.10）或平均（HR：0.38；95%CI：0.22 至 0.66）。慢跑者被分为轻度、中度和剧烈慢跑者。死亡率最低的是轻度慢跑者（HR：0.22；95%CI：0.10 至 0.47），其次是中度慢跑者（HR：0.66；95%CI：0.32 至 1.38）和剧烈慢跑者（HR：1.97；95%CI：0.48 至 8.14）。
研究结果表明，全因死亡率与慢跑的速度、数量和频率所标定的剂量之间呈 U 形关联。轻度和中度慢跑者的死亡率低于久坐不动的非慢跑者，而剧烈慢跑者的死亡率与久坐不动组无统计学差异。
