Department of Internal Medicine/Clinical Oncology, University Hospital of Basel, Basel, Switzerland.
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Cancer Res. 2015 Mar 1;75(5):803-7. doi: 10.1158/0008-5472.CAN-14-2717. Epub 2015 Feb 6.
Pregnancy at early, but not late age, has a strong and life-long protective effect against breast cancer. The expected overall increase in breast cancer incidence demands the development of a pharmaceutical mimicry of early-age pregnancy-mediated protection. Recently, converging results from rodent models and women on molecular and cellular mechanisms underlying the protective effect of early-age pregnancy have opened the door for translational studies on pharmacologic prevention against breast cancer. In particular, alterations in Wnt and TGFβ signaling in mammary stem/progenitor cells reveal new potential targets for preventive interventions, and thus might help to significantly reduce the incidence of breast cancer in the future.
早期妊娠而非晚期妊娠对乳腺癌具有强烈且持久的保护作用。预计乳腺癌发病率的整体增加要求开发一种类似于早期妊娠的药物模拟物来实现保护作用。最近，啮齿动物模型和女性的研究结果表明，早期妊娠保护作用的分子和细胞机制趋于一致，为针对乳腺癌的药物预防的转化研究开辟了道路。特别是，乳腺干/祖细胞中 Wnt 和 TGFβ信号的改变揭示了预防干预的新潜在靶点，因此有望在未来显著降低乳腺癌的发病率。
