Diaz-Buxo Jose A, Zeller-Knuth Corinne E, Rambaran Kerry Anne, Himmele Rainer
Fresenius Medical Care North America, Waltham, Mass., USA.
Blood Purif. 2015;39(1-3):45-9. doi: 10.1159/000368944. Epub 2015 Jan 20.
The aim in defining the dose of HHD is to provide sufficient dialysis required to possibly 'normalize' all abnormalities associated with renal failure in order improve patient survival and quality of life. Much progress has been made in defining the dose required to accomplish this goal, but the evidence is still far from robust. The main limitations are incomplete understanding of uremic toxins, their relative importance in causing uremic symptoms, and our inability to comprehensively assess dry weight.
This review provides guidance on realistic dosing of dialysis for the HHD patient based on the available evidence, where available, and alternative regimens that suit the individual's lifestyle and preferences.
HHD can easily accommodate alternative, intensive HD prescriptions, including daily and nocturnal HD. HHD provides prescription flexibility to fulfill patient needs while taking their preferences into account.
确定家庭血液透析（HHD）剂量的目的是提供足够的透析，以可能“纠正”与肾衰竭相关的所有异常情况，从而提高患者生存率和生活质量。在确定实现这一目标所需的剂量方面已经取得了很大进展，但证据仍远不够充分。主要局限性在于对尿毒症毒素的理解不完整、它们在引起尿毒症症状方面的相对重要性，以及我们无法全面评估干体重。
本综述基于现有证据，为HHD患者的实际透析剂量提供指导，以及适合个体生活方式和偏好的替代方案。
HHD可以轻松适应替代的强化血液透析处方，包括每日和夜间血液透析。HHD在考虑患者偏好的同时，提供了满足患者需求的处方灵活性。
