López-Tejero D, Arilla E, Colás B, Llobera M, Herrera E
Departamento de Bioquímica y Fisiologia, Facultad de Biologia, Universidad de Barcelona, España.
Biol Neonate. 1989;55(4-5):204-13. doi: 10.1159/000242918.
Some aspects of small intestine maturation have been studied in the newborns from chronic ethanol-treated pregnant rats (25% ethanol in drinking fluid) immediately after birth (before suckling) and after 30 days of life. Litters delivered by mothers fed ad libitum with a standard diet diluted 50% with cellulose were used as a nutritional control. At birth, pups from ethanol-treated mothers showed significant decreases in total intestinal length and thickness, low total lactase activity and low somatostatin intestinal content. The intestinal alterations of these neonatal parameters are not present in newborns from mothers on fiber-diluted diet. From delivery, pups from different experimental groups were nursed by normal lactating dams. At 30 days of age neither of those parameters differed among the groups. We propose that the low levels of total lactase activity in newborns from alcoholic mothers, that are a consequence of a lower intestinal mucosa content, are a direct effect of ethanol in utero on the fetal gastrointestinal system.
对慢性乙醇处理的怀孕大鼠（饮水中含25%乙醇）所产新生儿出生后即刻（哺乳前）及出生30天后小肠成熟的某些方面进行了研究。以随意喂食标准饮食且饮食中50%用纤维素稀释的母亲所产的窝仔作为营养对照。出生时，乙醇处理母亲所产幼崽的小肠总长度和厚度显著降低，乳糖酶总活性低，小肠生长抑素含量低。这些新生儿参数的肠道改变在食用纤维稀释饮食母亲所产新生儿中不存在。从出生起，不同实验组的幼崽由正常泌乳的母鼠哺育。30日龄时，这些参数在各组之间没有差异。我们认为，酒精性母亲所产新生儿乳糖酶总活性低是由于肠黏膜含量较低，这是子宫内乙醇对胎儿胃肠系统的直接影响。
