Mazzanti R, Debnam E S, Jenkins W J
Gut. 1987 Jan;28(1):56-60. doi: 10.1136/gut.28.1.56.
The effects of feeding a nutritionally adequate liquid diet containing 5% ethanol to rats over a four week period on intestinal lactase activity and the kinetics of jejunal galactose absorption in vivo have been determined. Both lactase activity and the maximum capacity for active, saturable galactose absorption (Jmax) were increased significantly after chronic ethanol ingestion. In contrast, uptake of the sugar via the phlorhizin-insensitive (passive) route was unaffected by ethanol. Our results imply the presence of an increased maturity of the enterocyte population on the villus surface in response to ethanol. The relevance of this work to uptake studies in alcoholics is briefly discussed.
已确定在四周时间内给大鼠喂食含5%乙醇的营养充足的流质饮食对肠道乳糖酶活性以及空肠半乳糖体内吸收动力学的影响。长期摄入乙醇后，乳糖酶活性以及主动、可饱和半乳糖吸收的最大能力（Jmax）均显著增加。相比之下，经由根皮苷不敏感（被动）途径的糖摄取不受乙醇影响。我们的结果表明，绒毛表面肠上皮细胞群因乙醇而成熟度增加。本文简要讨论了这项工作与酗酒者摄取研究的相关性。
