Dai Zhi-Jun, Wang Bao-Feng, Ma Yun-Feng, Kang Hua-Feng, Diao Yan, Zhao Yang, Lin Shuai, Lv Ye, Wang Meng, Wang Xi-Jing
Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China ; Center for Translational Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University Xi'an 710049, China.
Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China.
Int J Clin Exp Med. 2014 Dec 15;7(12):5031-40. eCollection 2014.
Previous studies have suggested that estrogen receptor-β (ESR2) rs1256049 polymorphism is associated with the susceptibility of cancer. However, the results are inconsistent. We performed a meta-analysis to evaluate the association between the rs1256049 polymorphism and cancer risk. PubMed, ISI Web of Knowledge, and Chinese National Knowledge Infrastructure (CNKI), were searched for eligible studies. The odds ratios (ORs) with 95% confidence interval (CI) were used to assess the strength of association. 22 studies including 22,994 cases and 30,514 controls were identified. There was no significant association between rs1256049 and cancer risk in the overall population. Stratified analysis by ethnicity revealed that the rs1256049 polymorphism was associated with cancer risk in Caucasians (A vs. G: OR = 1.09, 95% CI = 1.01-1.16; GA vs. GG: OR = 1.10, 95% CI = 1.02-1.18; AA+GA vs. GG: OR = 1.09, 95% CI = 1.02-1.17), but not in Asians. Further subgroup analysis by cancer type indicated that the rs1256049 polymorphism may contribute to prostate cancer risk (AA vs. GG: OR = 1.41, 95% CI = 1.02-1.96; AA vs. GG+GA: OR = 1.52, 95% CI = 1.10-2.10), whereas negative results were obtained for breast cancer in any genetic model. This meta-analysis suggested that the ESR2 rs1256049 polymorphism is a candidate gene polymorphism for cancer susceptibility in Caucasians, especially in prostate cancer.
先前的研究表明，雌激素受体-β（ESR2）rs1256049多态性与癌症易感性相关。然而，结果并不一致。我们进行了一项荟萃分析，以评估rs1256049多态性与癌症风险之间的关联。通过检索PubMed、科学网（ISI Web of Knowledge）和中国知网（CNKI）来查找符合条件的研究。采用比值比（OR）及95%置信区间（CI）来评估关联强度。共纳入22项研究，包括22,994例病例和30,514例对照。在总体人群中，rs1256049与癌症风险之间无显著关联。按种族进行分层分析显示，rs1256049多态性与白种人的癌症风险相关（A与G相比：OR = 1.09，95%CI = 1.01 - 1.16；GA与GG相比：OR = 1.10，95%CI = 1.02 - 1.18；AA + GA与GG相比：OR = 1.09，95%CI = 1.02 - 1.17），而与亚洲人无关。按癌症类型进行的进一步亚组分析表明，rs1256049多态性可能与前列腺癌风险有关（AA与GG相比：OR = 1.41，95%CI = 1.02 - 1.96；AA与GG + GA相比：OR = 1.52，95%CI = 1.10 - 2.10），而在任何遗传模型中乳腺癌均得到阴性结果。这项荟萃分析表明，ESR2 rs1256049多态性是白种人尤其是前列腺癌癌症易感性的一个候选基因多态性。
