Asker Muntecep, Asker Selvi, Kucuk Ugur, Kucuk Hilal Olgun, Ozbay Bulent
Department of Cardiology, Van Training and Research Hospital Van, Turkey.
Department of Chest Disease, Van Training and Research Hospital Van, Turkey.
Int J Clin Exp Med. 2014 Dec 15;7(12):5837-41. eCollection 2014.
The aim of the present study was to determine whether there is a relationship between coronary artery disease and pulmonary hypertension and whether pulmonary hypertension is an additional risk factor for the presence and extent of coronary artery disease in patients with chronic obstructive pulmonary disease. Patients diagnosed with chronic obstructive pulmonary disease and pulmonary hypertension, and undergone diagnostic coronary angiography for evaluation of suspected coronary artery disease constituted the study group. Patients were divided into two groups according to the presence or absence of coronary artery disease and compared for age, gender, accompanying chronic disease, and pulmonary function tests. A total of 95 patients were recruited in the study. Comparison of the groups revealed that two groups were significantly different on gender (p=0.029), presence of hypertension (p=0.027), and biomass (p=0.040). Correlation analysis of variables revealed that male gender (rs=0.224, p=0.029), hypertension (rs=0.227, p=0.07) were positively correlated with the presence of coronary artery disease. FEV1/FVC ratio (rs=-0.253, p=0.013) and sPAP (rs=-0.215, p=0.037) were negatively correlated with the presence of coronary artery disease. High prevalence of coronary artery disease in patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease was found. However, no correlation between the presence and severity of coronary artery disease and pulmonary hypertension was detected.
本研究的目的是确定冠状动脉疾病与肺动脉高压之间是否存在关联，以及肺动脉高压是否是慢性阻塞性肺疾病患者冠状动脉疾病的存在及严重程度的额外危险因素。被诊断为慢性阻塞性肺疾病和肺动脉高压，并接受诊断性冠状动脉造影以评估疑似冠状动脉疾病的患者构成了研究组。根据是否存在冠状动脉疾病将患者分为两组，并比较年龄、性别、伴随的慢性病和肺功能测试。本研究共招募了95名患者。两组比较显示，两组在性别（p = 0.029）、高血压的存在（p = 0.027）和体质指数（p = 0.040）方面存在显著差异。变量的相关性分析显示，男性（rs = 0.224，p = 0.029）、高血压（rs = 0.227，p = 0.07）与冠状动脉疾病的存在呈正相关。第一秒用力呼气容积/用力肺活量比值（rs = -0.253，p = 0.013）和收缩期肺动脉压（rs = -0.215，p = 0.037）与冠状动脉疾病的存在呈负相关。发现继发于慢性阻塞性肺疾病的肺动脉高压患者中冠状动脉疾病的患病率较高。然而，未检测到冠状动脉疾病的存在和严重程度与肺动脉高压之间的相关性。
