Ahmadi Ali, Hashemi Nazari Seyed Saeed, Mobasheri Mahmoud
1. Ph.D of Epidemiology, Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2. Assistant Professor of Epidemiology, Department of Epidemiology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Med J Islam Repub Iran. 2014 Jul 27;28:83. eCollection 2014.
The present study compared the differences between survivals of patients with colorectal cancer according to their ethnicity adjusted for other predictors of survival.
In this prospective cohort study patients were followed up from definite diagnosis of colorectal cancer to death. Totally, 2431 person-year follow-ups were undertaken for 1127 colorectal cancer patients once every six months. The data were analyzed by stata software using bivariate analysis, multivariate analysis, and Cox regression.
The age at diagnosis was significantly different between men and women (p<0.03). 61.2% were male and the rest were female. Most patients were Fars (51.2%), followed by Turciks (21.5%), Kurds (8.2%), and 7.5% Lurs. Of the patients, 75% had a survival of more than 2.72 years, 50% a survival of 5.83 years, and 25% longer than 13.1 years after diagnosis. Risk ratio was significantly different among ethnics (p<0.05). The variables of ethnicity, being non married, tumor grade, family history of cancer, and smoking were considered as determinants of the patients' survival in Cox regression model. The median survival time in Fars, Kurds, Lurs, Turks and other ethnics was 5.83, 2.44, 5.49, and 8.52 years, respectively.
Ethnicity and access to healthcare are predictors of survival of patients with colorectal cancer which may define priorities in controlling cancer and implementing interventional and prevention plans.
本研究比较了根据种族调整其他生存预测因素后，结直肠癌患者生存率之间的差异。
在这项前瞻性队列研究中，患者从确诊结直肠癌开始随访直至死亡。总共对1127例结直肠癌患者进行了2431人年的随访，每六个月随访一次。使用stata软件对数据进行双变量分析、多变量分析和Cox回归分析。
男女确诊时的年龄存在显著差异（p<0.03）。61.2%为男性，其余为女性。大多数患者是法尔斯人（51.2%），其次是突厥人（21.5%）、库尔德人（8.2%）和卢尔人（7.5%）。在这些患者中，75%的患者生存时间超过2.72年，50%的患者生存时间为5.83年，25%的患者在确诊后生存时间超过13.1年。不同种族之间的风险比存在显著差异（p<0.05）。在Cox回归模型中，种族、未婚、肿瘤分级、癌症家族史和吸烟等变量被视为患者生存的决定因素。法尔斯人、库尔德人、卢尔人、突厥人和其他种族的中位生存时间分别为5.83年、2.44年、5.49年和8.52年。
种族和医疗保健可及性是结直肠癌患者生存的预测因素，这可能为控制癌症以及实施干预和预防计划确定优先事项。
