Ali Sheikh Md Sayed, Xia Ke, Li Fei, Deng Xu, Salma Umme, Deng Hai, Wei Wei Liu, Yang Tian-Lun, Peng Jun
Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410078, China.
Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410078, China ; Center for Vascular Biology and Inflammation, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Biomed Res Int. 2015;2015:740301. doi: 10.1155/2015/740301. Epub 2015 Jan 15.
The purpose of this study was to evaluate the diagnostic value of circulating miR-765 and miR-149 as noninvasive early biomarkers for geriatric coronary artery disease (CAD) patients. A total of 69 angiographically documented CAD patients including 37 stable CAD (72.9 ± 4.2 years) and 32 unstable CAD (72.03 ± 4.3 years) and 20 healthy subjects (71.7 ± 5.2 years), matched for age, sex, smoking habit, hypertension, and diabetes, were enrolled in this study. Compared with healthy subjects, circulating miR-765 levels were increased by 2.9-fold in stable CAD and 5.8-fold in unstable CAD patients, respectively, while circulating miR-149 levels were downregulated by 3.5-fold in stable CAD and 4.2-fold in unstable CAD patients, respectively. Furthermore, plasma levels of miR-765 were found to be positively correlated with ages within control, stable, and unstable groups. The ROC curves of miR-765 and miR-149 represented significant diagnostic values with an area under curve (AUC) of 0.959, 0.972 and 0.938, 0.977 in stable CAD patients and unstable CAD patients as compared with healthy subjects, respectively. Plasma levels of miR-765 and miR-149 might be used as noninvasive biomarkers for the diagnosis of CAD in geriatric people.
本研究的目的是评估循环miR - 765和miR - 149作为老年冠状动脉疾病（CAD）患者非侵入性早期生物标志物的诊断价值。本研究共纳入69例经血管造影证实的CAD患者，包括37例稳定型CAD患者（72.9±4.2岁）和32例不稳定型CAD患者（72.03±4.3岁），以及20名健康受试者（71.7±5.2岁），这些受试者在年龄、性别、吸烟习惯、高血压和糖尿病方面相匹配。与健康受试者相比，稳定型CAD患者循环miR - 765水平分别升高2.9倍，不稳定型CAD患者升高5.8倍；而稳定型CAD患者循环miR - 149水平分别下调3.5倍，不稳定型CAD患者下调4.2倍。此外，发现miR - 765的血浆水平在对照组、稳定组和不稳定组中均与年龄呈正相关。与健康受试者相比，miR - 765和miR - 149的ROC曲线在稳定型CAD患者和不稳定型CAD患者中分别具有显著的诊断价值，曲线下面积（AUC）分别为0.959、0.972和0.938、0.977。miR - 765和miR - 149的血浆水平可能用作老年人CAD诊断的非侵入性生物标志物。
