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成人巨大先天性黑素细胞痣的治疗:巨大先天性黑素细胞痣当前管理方法的综述

Treatment of a giant congenital melanocytic nevus in the adult: review of the current management of giant congenital melanocytic nevus.

作者信息

Su Jeannie J, Chang Daniel K, Mailey Brian, Gosman Amanda

机构信息

From the Division of Plastic Surgery, Department of Surgery, University of California, San Diego, San Diego, CA.

出版信息

Ann Plast Surg. 2015 May;74 Suppl 1:S57-61. doi: 10.1097/SAP.0000000000000433.

Abstract

Giant congenital melanocytic nevi (GCMNs) create cosmetic disfigurements and pose risk for malignant transformation. Adult GCMN cases are uncommon because most families opt for surgical treatment during childhood. We review the current literature on GCMN and present an interesting case of an adult with a GCMN encompassing the entire back with painful nodules exhibiting gross involvement of his back musculature, without pathologic evidence of malignancy. Surgical management was deferred in childhood because of parental desires to allow the patient to make his own decision, and treatment in adulthood was pursued on the basis of the significant impairment of the patient's quality of life and self-esteem due to the massive size and deforming nature of the nevus. The treatment strategy used for this young adult male patient involved a massive en bloc excision of the GCMN with partial resection of the latissimus dorsi, followed by a 5-week staged reconstructive process using dermal regenerative matrices and split-thickness skin grafting. Because of the shift in GCMN management from early surgical management to more conservative management, we may see an increase in adult cases of GCMN. Thus, it is critical to better understand the controversy surrounding early versus delayed management of GCMN.

摘要

巨大先天性黑素细胞痣(GCMNs)会造成容貌损毁,并存在恶变风险。成人GCMN病例并不常见,因为大多数家庭会在儿童期选择手术治疗。我们回顾了关于GCMN的当前文献,并呈现了一个有趣的病例,一名成年患者的GCMN覆盖整个背部,伴有疼痛性结节,背部肌肉组织明显受累,但无恶性病变的病理证据。由于父母希望让患者自己做决定,该患者在儿童期未进行手术治疗,而在成年期,鉴于痣的巨大尺寸和变形性质对患者生活质量和自尊造成的严重损害,遂进行了治疗。针对这名青年男性患者的治疗策略包括整块切除GCMN并部分切除背阔肌,随后使用真皮再生基质和中厚皮片移植进行为期5周的分期重建过程。由于GCMN的管理方式从早期手术管理转向了更为保守的管理,我们可能会看到成人GCMN病例有所增加。因此,更好地理解围绕GCMN早期与延迟管理的争议至关重要。

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