巨大多发性先天性黑素细胞痣恶变风险：一项 20 年单中心研究。

Risk of Malignant Transformation Arising From Giant Congenital Melanocytic Nevi: A 20-year Single-center Study.

机构信息

Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.

Seoul National University College of Medicine, Seoul, Republic of Korea.

出版信息

Dermatol Surg. 2022 Feb 1;48(2):171-175. doi: 10.1097/DSS.0000000000003341.

DOI:10.1097/DSS.0000000000003341

PMID:34935754

Abstract

BACKGROUND

Although giant congenital melanocytic nevus (GCMN) is regarded as premalignant, the incidence and risk factors of malignant transformation are controversial.

OBJECTIVE

This study aimed to share the authors' surgical experience with GCMNs and provide data on their demographics, malignant transformation, and prognosis.

METHODS

This single-center, consecutive study included 152 patients with GCMN who visited this center from March 2000 to February 2020. Their medical documentation was reviewed retrospectively, and the nevi were classified according to the size as follows: Group 1, 10 to 19.9 cm (n = 45); Group 2, 20 to 39.9 cm (n = 62); and Group 3, ≥40 cm (n = 45).

RESULTS

Seven malignancies were found (4.6%; 4 melanomas, 2 rhabdomyosarcomas [RMS], and 1 malignant peripheral nerve sheath tumor [MPNST]). The risk increased according to the nevus size (2.2% in Group 1, 3.2% in Group 2, and 8.9% in Group 3) but the difference was not statistically significant (p = .3305).

CONCLUSION

Malignant transformation from GCMN cannot be ignored. It can include transformation into melanoma, RMS, and MPNST. Early surgical resection and regular follow-up should be performed in patients with nevi ≥10 cm.

摘要

背景

尽管先天性巨大黑素细胞痣（GCMN）被认为是癌前病变，但恶性转化的发生率和危险因素仍存在争议。

目的

本研究旨在分享作者在 GCMN 方面的手术经验，并提供有关其人口统计学、恶性转化和预后的数据。

方法

这是一项单中心、连续研究，纳入了 2000 年 3 月至 2020 年 2 月期间来我院就诊的 152 例 GCMN 患者。回顾性分析其病历资料，并根据大小将痣分为以下三组：1 组，10 至 19.9 cm（n = 45）；2 组，20 至 39.9 cm（n = 62）；3 组，≥40 cm（n = 45）。