Schulz Karl-Heinz, Patra Stefan, Spielmann Hannah, Klapdor Silke, Schlüter Kathrin, van Eckert Sandra
Institut und Poliklinik für Medizinische Psychologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Universitäres Kompetenzzentrum für Sport- und Bewegungsmedizin (Athleticum), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
SAGE Open Med. 2017 Dec 21;5:2050312117743674. doi: 10.1177/2050312117743674. eCollection 2017.
Early detection of limited physical activity and nutritional deficiencies in cancer survivors could contribute to early treatment and preservation of quality of life. The aim of this study is to describe the association of physical condition and nutritional status with fatigue and quality of life in oncological out-patients.
Data in this descriptive study was collected on bioelectrical impedance analysis, postural stability (stability index), body mass index, Karnofsky Index, quality of life (Short-Form 36-Item Health Survey) and fatigue (multidimensional fatigue inventory-20) in a consecutive sample of 203 oncological out-patients. Phase angle was calculated from bioelectrical impedance analysis. Values were intercorrelated and compared to appropriate standard values.
Phase angle and stability index outcomes were far below the values of a healthy population of similar age (p < 0.001). Quality of life was significantly lower than in the normal population (p < 0.001), and the level of fatigue was significantly higher (p < 0.001). Phase angle correlated with Karnofsky Index (p = 0.002) and Short-Form 36-Item Health Survey Summary physical function (p < 0.001). Furthermore, multidimensional fatigue inventory-20 scales 'physical fatigue' and 'reduced activity' were significantly associated with phase angle (p = 0.04, p = 0.005). Stability indices correlated with Short-Form 36-Item Health Survey physical function.
The physical condition and the nutritional status are key components determining the individual quality of life of oncological out-patients. These variables also showed an association with the manifestation of fatigue. Results highlight the need for interdisciplinary cooperation to detect physical, nutritional and psychological deficiencies in oncological out-patients.
早期发现癌症幸存者的身体活动受限和营养缺乏情况有助于早期治疗并维持生活质量。本研究旨在描述肿瘤门诊患者的身体状况和营养状况与疲劳及生活质量之间的关联。
在这项描述性研究中，对203例肿瘤门诊患者的连续样本收集了生物电阻抗分析、姿势稳定性（稳定指数）、体重指数、卡诺夫斯基指数、生活质量（简明健康状况调查简表）和疲劳（多维疲劳量表-20）的数据。通过生物电阻抗分析计算相位角。对各项数值进行相互关联分析，并与适当的标准值进行比较。
相位角和稳定指数结果远低于年龄相仿的健康人群的值（p < 0.001）。生活质量显著低于正常人群（p < 0.001），疲劳程度显著更高（p < 0.001）。相位角与卡诺夫斯基指数（p = 0.002）和简明健康状况调查简表的总体身体功能（p < 0.001）相关。此外，多维疲劳量表-20的“身体疲劳”和“活动减少”量表与相位角显著相关（p = 0.04，p = 0.005）。稳定指数与简明健康状况调查简表的身体功能相关。
身体状况和营养状况是决定肿瘤门诊患者个体生活质量的关键因素。这些变量还与疲劳的表现相关。结果凸显了跨学科合作以检测肿瘤门诊患者身体、营养和心理缺陷的必要性。
