尼日利亚孕妇血浆中的锌和铜浓度。

Zinc and copper concentration in plasma of pregnant women in Nigeria.

作者信息

Okonofua F E, Amole F A, Emofurieta W O, Ugwu N C

机构信息

Department of Obstetrics and Gynaecology, Obafemi Awolowo University, Ile-Ife, Nigeria.

出版信息

Int J Gynaecol Obstet. 1989 May;29(1):19-23. doi: 10.1016/0020-7292(89)90123-9.

DOI:10.1016/0020-7292(89)90123-9

PMID:2566523

Abstract

The concentration of plasma zinc and copper were determined by atomic absorption spectrophotometry in 58 Nigerian women at various times in pregnancy and compared with those of 11 non-pregnant controls. The results showed 67.5% decrease in zinc and 100% increase in copper over non-pregnant levels at the end of pregnancy. The mean plasma zinc levels were appreciably lower and copper the same as published values for Caucasian women at similar periods in pregnancy. Furthermore, there was no correlation between plasma zinc and copper and neonatal birthweight. We conclude that (1) a significant proportion of pregnant women in Nigeria have biochemical hypozincemia; (2) this hypozincemia is not responsible for fetal growth retardation in this population and (3) there is at present no justification for giving routine zinc supplementation to pregnant women in Nigeria.

摘要

采用原子吸收分光光度法测定了58名尼日利亚孕妇在孕期不同阶段的血浆锌和铜浓度，并与11名非孕妇对照组进行了比较。结果显示，妊娠末期锌浓度较非孕期水平降低了67.5%，铜浓度升高了100%。孕期相同阶段，尼日利亚孕妇的平均血浆锌水平明显低于白种女性已公布的值，而铜水平则与之相同。此外，血浆锌和铜与新生儿出生体重之间没有相关性。我们得出以下结论：（1）尼日利亚很大一部分孕妇存在生化性低锌血症；（2）这种低锌血症并非该人群胎儿生长受限的原因；（3）目前没有理由对尼日利亚孕妇进行常规补锌。