特非那定在正常志愿者体内抗胆碱能活性的研究。

A study of the anticholinergic activity of terfenadine in normal volunteers.

作者信息

Vargas R, McMahon F G, Ryan J R

机构信息

Clinical Research Center, New Orleans, Louisiana 70122.

出版信息

J Int Med Res. 1989 Mar-Apr;17(2):157-61. doi: 10.1177/030006058901700207.

DOI:10.1177/030006058901700207

PMID:2566537

Abstract

The anticholinergic effects of single doses of terfenadine, chlorpheniramine and atropine on salivary flow were compared with those of placebo in a double-blind crossover study in 21 normal adults. Salivary flow was measured immediately before administering study medications and 3 h after dosing, for the evaluation of anticholinergic activity. Mean salivary flow decreased significantly after administration of chlorpheniramine and atropine (P less than 0.01 and P less than 0.001, respectively), and was unchanged by terfenadine and placebo, indicating that terfenadine does not possess detectable anticholinergic activity. Mild drowsiness was reported by 57% and 29% of subjects who received chlorpheniramine and terfenadine, respectively.

摘要

在一项针对21名正常成年人的双盲交叉研究中，将单剂量特非那定、氯苯那敏和阿托品对唾液分泌的抗胆碱能作用与安慰剂进行了比较。在服用研究药物前及给药3小时后测量唾液分泌量，以评估抗胆碱能活性。服用氯苯那敏和阿托品后，平均唾液分泌量显著下降（分别为P<0.01和P<0.001），而特非那定和安慰剂对其无影响，表明特非那定不具有可检测到的抗胆碱能活性。分别有57%和29%接受氯苯那敏和特非那定的受试者报告有轻度嗜睡。