Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, New York, NY 10003, USA.
Surv Ophthalmol. 2013 Jan-Feb;58(1):77-85. doi: 10.1016/j.survophthal.2012.04.003. Epub 2012 Sep 14.
Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a "pseudomelanoma", reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.
神经鞘瘤是一种肿瘤性施万细胞的增殖。虽然头颈部的神经鞘瘤很常见，但眼内组织很少受到影响。葡萄膜神经鞘瘤恰当地被称为“假黑素瘤”，反映了其在临床与葡萄膜恶性黑色素瘤区分的困难。我们目前对眼内神经鞘瘤的大部分认识仅限于病例报告、短篇病例系列和非全面的文献综述。文献中有 3 篇关于葡萄膜神经鞘瘤伴巩膜外扩展的孤立报告，但这种生长模式的预后意义尚不清楚。我们报告了一例脉络膜神经鞘瘤伴巩膜外扩展，并回顾了 46 例先前报道的葡萄膜神经鞘瘤病例，以阐明这些眼内肿瘤的临床和病理特征，特别强调了伴眼外扩展的神经鞘瘤。
