聚合酶链反应显示日本女性正常宫颈中人类乳头瘤病毒16、18和33型DNA的患病率相对较低。
Relatively low prevalence of human papillomavirus 16, 18 and 33 DNA in the normal cervices of Japanese women shown by polymerase chain reaction.
作者信息
Nishikawa A, Fukushima M, Shimada M, Yamakawa Y, Shimano S, Kato I, Fujinaga K
机构信息
Department of Obstetrics and Gynecology, Cancer Research Institute, Sapporo Medical College.
出版信息
Jpn J Cancer Res. 1991 May;82(5):532-8. doi: 10.1111/j.1349-7006.1991.tb01883.x.
Ninety-two cervical scrapes and tissues, obtained from cytologically or histologically normal cervices of Japanese women, were examined for the presence of human papillomavirus (HPV) 16, 18 and 33 DNA by the polymerase chain reaction (PCR) method. Five out of 92 cases were HPV 16 DNA-positive, but neither HPV 18 nor 33 DNA was detected. The HPV (type 16, 18 and 33) prevalence rate in pregnant women, including postpartum, was 10% (3/31), which was higher than that in non-pregnant women. In two HPV 16-positive cases, we detected HPV 16 DNA again 2 months later. HPV (type 16, 18 and 33) prevalence in normal cervices was shown to be relatively low. However, it is very important to follow up the HPV-positive cases in cytologically normal cervices in order to elucidate the relation between HPV infection and the progression of cervical cancer.
从日本女性细胞学或组织学正常的宫颈获取了92份宫颈刮片和组织样本，采用聚合酶链反应（PCR）方法检测人乳头瘤病毒（HPV）16、18和33型DNA的存在情况。92例样本中有5例HPV 16 DNA呈阳性，但未检测到HPV 18和33 DNA。包括产后妇女在内的孕妇中HPV（16、18和33型）感染率为10%（3/31），高于非孕妇。在2例HPV 16阳性病例中，2个月后再次检测到HPV 16 DNA。正常宫颈中HPV（16、18和33型）感染率相对较低。然而，对细胞学正常宫颈中的HPV阳性病例进行随访，对于阐明HPV感染与宫颈癌进展之间的关系非常重要。
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