泪点塞：一种用于治疗干眼症和眼部持续药物输送的医疗器械。
Punctal plug: a medical device to treat dry eye syndrome and for sustained drug delivery to the eye.
机构信息
College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT, USA; Department of Pharmaceutics and Pharmaceutical Sciences, University of Utah, Salt Lake City, UT, USA.
Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.
出版信息
Drug Discov Today. 2015 Jul;20(7):884-9. doi: 10.1016/j.drudis.2015.01.013. Epub 2015 Feb 7.
Punctal plugs (PPs) are miniature medical implants that were initially developed for the treatment of dry eyes. Since their introduction in 1975, many PPs made from different materials and designs have been developed. PPs, albeit generally successful, suffer from drawbacks such as epiphora and suppurative canaliculitis. To overcome these issues intelligent designs of PPs were proposed (e.g. SmartPLUG™ and Form Fit™). PPs are also gaining interest among pharmaceutical scientists for sustaining drug delivery to the eye. This review aims to provide an overview of PPs for dry eye treatment and drug delivery to treat a range of ocular diseases. It also discusses current challenges in using PPs for ocular diseases.
泪点塞（PPs）是微型医疗植入物，最初是为治疗干眼症而开发的。自 1975 年推出以来，已经开发出许多由不同材料和设计制成的 PPs。PPs 虽然总体上很成功，但也存在一些缺点，例如溢泪和化脓性泪小管炎。为了克服这些问题，人们提出了 PPs 的智能设计（例如 SmartPLUG™ 和 Form Fit™）。PPs 也在眼科药物科学家中引起了兴趣，以维持药物向眼睛的输送。本综述旨在概述 PPs 在干眼症治疗和药物输送方面的应用，以治疗一系列眼部疾病。它还讨论了使用 PPs 治疗眼部疾病的当前挑战。
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