肥大细胞在黏膜免疫中的潜在效应和免疫调节功能。
Potential effector and immunoregulatory functions of mast cells in mucosal immunity.
作者信息
Reber L L, Sibilano R, Mukai K, Galli S J
机构信息
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
1] Department of Pathology, Stanford University School of Medicine, Stanford, California, USA [2] Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.
出版信息
Mucosal Immunol. 2015 May;8(3):444-63. doi: 10.1038/mi.2014.131. Epub 2015 Feb 11.
Mast cells (MCs) are cells of hematopoietic origin that normally reside in mucosal tissues, often near epithelial cells, glands, smooth muscle cells, and nerves. Best known for their contributions to pathology during IgE-associated disorders such as food allergy, asthma, and anaphylaxis, MCs are also thought to mediate IgE-associated effector functions during certain parasite infections. However, various MC populations also can be activated to express functional programs--such as secreting preformed and/or newly synthesized biologically active products--in response to encounters with products derived from diverse pathogens, other host cells (including leukocytes and structural cells), damaged tissue, or the activation of the complement or coagulation systems, as well as by signals derived from the external environment (including animal toxins, plant products, and physical agents). In this review, we will discuss evidence suggesting that MCs can perform diverse effector and immunoregulatory roles that contribute to homeostasis or pathology in mucosal tissues.
肥大细胞（MCs）是造血起源的细胞，通常存在于黏膜组织中，常靠近上皮细胞、腺体、平滑肌细胞和神经。MCs最出名的是在与IgE相关的疾病（如食物过敏、哮喘和过敏反应）中对病理过程的作用，它们也被认为在某些寄生虫感染期间介导与IgE相关的效应功能。然而，各种MC群体也可以被激活以表达功能程序，例如分泌预先形成的和/或新合成的生物活性产物，以响应与来自不同病原体、其他宿主细胞（包括白细胞和结构细胞）、受损组织或补体或凝血系统激活的产物的接触，以及来自外部环境的信号（包括动物毒素、植物产物和物理因子）。在这篇综述中，我们将讨论证据表明MCs可以发挥多种效应和免疫调节作用，这些作用有助于黏膜组织中的稳态或病理过程。
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