Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
J Am Chem Soc. 2015 Mar 4;137(8):2852-5. doi: 10.1021/jacs.5b00546. Epub 2015 Feb 19.
A 4,4'-bipyridine-based catalyst system for diboration of pyrazine derivatives was established. The catalyst cycle consists of the following two steps: (1) reductive addition of the boron-boron bond of bis(pinacolato)diboron to 4,4'-bipyridine to form N,N'-diboryl-4,4'-bipyridinylidene and (2) oxidative boryl transfer from the intermediate to pyrazine to give N,N'-diboryl-1,4-dihydropyrazine with regeneration of 4,4'-bipyridine.
建立了一种用于吡嗪衍生物的双硼化反应的 4,4'-联吡啶基催化剂体系。催化剂循环包括以下两个步骤：（1）双（频哪醇）二硼的硼-硼键还原加成到 4,4'-联吡啶上，形成 N,N'-二硼基-4,4'-联吡啶亚基；（2）从中间体到吡嗪的氧化硼基转移，得到 N,N'-二硼基-1,4-二氢吡嗪，同时再生 4,4'-联吡啶。
