Salvadó M Josepa, Casanova Ester, Fernández-Iglesias Anabel, Arola Lluis, Bladé Cinta
Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Tarragona, Spain.
Food Funct. 2015 Apr;6(4):1053-71. doi: 10.1039/c4fo01035c.
Obesity is a multifactorial disorder involving an abnormal or excessive amount of body fat. Obese people have a very high probability of developing metabolic syndrome, a condition in which cholesterol, lipid, and glucose levels rise, causing diabetes and heart disease. From the point of view of energy balance, the main contributors to obesity are excessive energy intake, inadequate energy expenditure and metabolic malfunctions. For this reason, health organisations are working to implement policies and plans to promote healthy eating and active living. However, these measures have not yet proven sufficient to combat this worldwide epidemic; therefore, drugs and bioactive compounds are being investigated to complement the existing strategies. In the present review, we discuss the available data regarding the modulation of obesity by proanthocyanidin rich extracts. Because studies with human subjects are very scarce, we focus on studies using laboratory animals. The results of in vitro studies are included because, although they cannot be directly extrapolated to the biological effects of proanthocyanidin, they can reveal some mechanisms of action.
肥胖是一种多因素疾病，涉及体内脂肪异常或过多。肥胖人群患代谢综合征的可能性非常高，代谢综合征是一种胆固醇、脂质和葡萄糖水平升高，从而引发糖尿病和心脏病的病症。从能量平衡的角度来看，肥胖的主要成因是能量摄入过多、能量消耗不足以及代谢功能紊乱。因此，卫生组织正在努力实施各项政策和计划，以促进健康饮食和积极生活方式。然而，这些措施尚未被证明足以对抗这一全球流行病；因此，正在研究药物和生物活性化合物以补充现有策略。在本综述中，我们讨论了有关富含原花青素提取物对肥胖调节作用的现有数据。由于针对人类受试者的研究非常稀少，我们重点关注使用实验动物的研究。体外研究结果也被纳入，因为尽管它们不能直接外推到原花青素的生物学效应，但可以揭示一些作用机制。
