Perga S, Montarolo F, Martire S, Berchialla P, Malucchi S, Bertolotto A
Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy; University Hospital San Luigi Gonzaga, Neurobiology Unit, Neurologia 2 - CReSM (Centro Riferimento Regionale Sclerosi Multipla), Orbassano, TO, Italy.
Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy; University Hospital San Luigi Gonzaga, Neurobiology Unit, Neurologia 2 - CReSM (Centro Riferimento Regionale Sclerosi Multipla), Orbassano, TO, Italy.
J Neuroimmunol. 2015 Feb 15;279:75-8. doi: 10.1016/j.jneuroim.2015.01.004. Epub 2015 Jan 21.
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system caused by a complex interaction between multiple genes and environmental factors. HLA region is the strongest susceptibility locus, but recent huge genome-wide association studies identified new susceptibility genes. Among these, BACH2, PTGER4, RGS1 and ZFP36L1 were highlighted. Here, a gene expression analysis revealed that three of them, namely BACH2, PTGER4 and ZFP36L1, are down-regulated in MS patients' blood cells compared to healthy subjects. Interestingly, all these genes are involved in the immune system regulation with predominant anti-inflammatory role and their reduction could predispose to MS development.
多发性硬化症（MS）是一种中枢神经系统的自身免疫性炎症性疾病，由多个基因与环境因素之间的复杂相互作用引起。HLA区域是最强的易感位点，但最近大规模的全基因组关联研究发现了新的易感基因。其中，BACH2、PTGER4、RGS1和ZFP36L1受到关注。在此，一项基因表达分析显示，与健康受试者相比，MS患者血细胞中的其中三个基因，即BACH2、PTGER4和ZFP36L1表达下调。有趣的是，所有这些基因都参与免疫系统调节，具有主要的抗炎作用，它们的表达降低可能易患MS。
