Leaf R C, Wnek D J, Gay P E, Corcia R M, Lamon S
Psychopharmacologia. 1975 Oct 14;44(1):23-8. doi: 10.1007/BF00421178.
Chlordiazepoxide HCl, at dose levels from 2.5 mg/kg to 80 mg/kg, significantly increased the low base rates of mouse killing (3-9%) observed in large samples (N = 100/dose) of Holtzman strain albino male rats. Maximal killing rates were obtained at doses from 7.5 mg/kg to 20 mg/kg. Diazepam was equally effective, and several times more potent than chlordiazepoxide. Pentobarbital did not increase killing. Killing induced by chlordiazepoxide was blocked by d-amphetamine SO4, but not by l-amphetamine, at dose levels similar to those that block undrugged killing in this strain (ED50 = 1.5 mg/kg). Unlike pilocarpine-induced killing, the effects of chlordiazepoxide were not increased or decreased significantly by either peripherally or centrally active anticholinergic drugs, over wide dose ranges of these agents; nor were the effects of chlordiazepoxide increased by repeated daily administration.
盐酸氯氮卓，剂量从2.5毫克/千克至80毫克/千克，显著提高了在大量样本（每个剂量N = 100）的霍尔茨曼品系白化雄性大鼠中观察到的低杀鼠基线率（3 - 9%）。在7.5毫克/千克至20毫克/千克的剂量下获得最大杀鼠率。地西泮同样有效，且效力比氯氮卓强几倍。戊巴比妥不增加杀鼠行为。氯氮卓诱导的杀鼠行为在类似于该品系中阻断未用药杀鼠行为的剂量水平（ED50 = 1.5毫克/千克）下，被右旋硫酸苯丙胺阻断，但不被左旋苯丙胺阻断。与毛果芸香碱诱导的杀鼠行为不同，在这些药物的广泛剂量范围内，外周或中枢活性抗胆碱能药物均未显著增加或降低氯氮卓的作用；每日重复给药也未增加氯氮卓的作用。
