Kostowski W, Valzelli L, Baiguerra G
Neuropharmacology. 1986 Jul;25(7):757-61. doi: 10.1016/0028-3908(86)90092-4.
The activity of chronic (3 weeks) treatment with the triazolobenzodiazepines, alprazolam and adinazolam, on clonidine- and apomorphine-induced aggression were studied. Adinazolam, like desipramine, potentiated aggression induced by clonidine while diazepam and alprazolam completely abolished it. In the apomorphine-induced aggression, adinazolam suppressed both aggressivity and stereotypy, while diazepam slightly potentiated it. Alprazolam did not modify the effect of aggression induced by apomorphine. On the whole, while adinazolam seemed to develop an activity closer to that of a classical antidepressant like desipramine, alprazolam appeared to be more similar to the benzodiazepines on clonidine-induced aggression in mice. Compared to desipramine and diazepam, adinazolam left these two effects induced by apomorphine almost unchanged. The experiments performed showed differences between the profiles of action of the two triazolobenzodiazepines studied.
研究了三唑并苯二氮䓬类药物阿普唑仑和阿地唑仑进行慢性（3周）治疗对可乐定和阿扑吗啡诱导的攻击行为的作用。与地昔帕明一样，阿地唑仑增强了可乐定诱导的攻击行为，而地西泮和阿普唑仑则完全消除了这种行为。在阿扑吗啡诱导的攻击行为中，阿地唑仑抑制了攻击性和刻板行为，而地西泮则略有增强。阿普唑仑未改变阿扑吗啡诱导的攻击行为的效果。总体而言，阿地唑仑似乎表现出与地昔帕明等经典抗抑郁药更相似的活性，而在小鼠可乐定诱导的攻击行为方面，阿普唑仑似乎与苯二氮䓬类药物更相似。与地昔帕明和地西泮相比，阿地唑仑使阿扑吗啡诱导的这两种效应几乎保持不变。所进行的实验表明，所研究的两种三唑并苯二氮䓬类药物的作用谱存在差异。
