Goyle S, Maurya A K, Rout U K, Kailash S, Maheshwari M C
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Teratog Carcinog Mutagen. 1989;9(1):7-14. doi: 10.1002/tcm.1770090103.
Sister chromatid exchange (SCE) frequency, a sensitive indicator in mutagenicity testing, and mitotic index (MI) have been studied to observe genotoxic effects in epileptic patients on routine combinations of anticonvulsant therapy. All patients, both male and female and from various age groups, revealed an increased frequency of SCE per metaphase and a low MI (P less than 0.001) with respect to controls. A nonsignificant decrease in SCE frequency has been observed with an increase in the age of onset of epilepsy. Although the SCE frequency increased and the MI decreased in some groups with respect to the duration of epilepsy, there was no difference observed in SCE frequency with the duration of therapy.
姐妹染色单体交换（SCE）频率是致突变性测试中的一个敏感指标，对癫痫患者采用抗惊厥治疗的常规组合方案，通过研究有丝分裂指数（MI）来观察遗传毒性效应。所有患者，无论男女，来自各个年龄组，与对照组相比，每个中期的SCE频率增加，且MI较低（P小于0.001）。随着癫痫发病年龄的增加，观察到SCE频率有不显著的下降。尽管在某些组中，SCE频率随癫痫病程增加而上升，MI则下降，但未观察到SCE频率随治疗时间有差异。
