Sardaş S, Ada M, Karakaya A E, Aydin N
University of Gazi, Department of Toxicology, Faculty of Pharmacy, Ankara, Turkey.
Mutat Res. 1994 Aug;313(1):21-4. doi: 10.1016/0165-1161(94)90029-9.
Sister-chromatid exchanges (SCE) have been studied to analyze genotoxic effects in epileptic patients on anticonvulsant therapy. All patients had an increased frequency of SCE per metaphase (p < 0.001) compared to controls, indicating a genotoxic effect of anticonvulsant drugs.
为分析抗惊厥治疗对癫痫患者的遗传毒性作用，对姐妹染色单体交换（SCE）进行了研究。与对照组相比，所有患者每个中期的SCE频率均增加（p < 0.001），表明抗惊厥药物具有遗传毒性作用。
