Goyle S, Maurya A K, Kailash S, Maheshwari M C
Epilepsia. 1987 Jan-Feb;28(1):81-6. doi: 10.1111/j.1528-1157.1987.tb03628.x.
Therapy with anticonvulsant drugs has often been found to result in somatic chromosome aberrations in adult patients. There is also the possibility of epileptic fathers or mothers playing a role in the production of congenital malformations in their offspring. We have used the technique of sister chromatid exchange (SCE), a sensitive indicator of mutagenicity, to observe the mutagenic susceptibility in both male and female epileptic patients in different age groups prior to and after anticonvulsant therapy, and with respect to control. The frequency of SCE was significantly higher in all the age groups for treated and untreated cases compared with control. Between treated and untreated subjects in age group 26-50 years, a significantly higher SCE frequency was observed in the untreated patients (p less than 0.01). Similarly, untreated male patients showed a significantly higher SCE frequency (p less than 0.025) compared with treated male patients. Although the results of this study provide a general assessment of mutagenicity in epileptic patients that agrees with other studies and emphasizes the role of the disease in the higher occurrence of congenital malformation in their offspring, the importance of higher SCE frequency in untreated patients remains to be explained in further studies.
人们常常发现，抗惊厥药物治疗会导致成年患者出现体细胞染色体畸变。癫痫患者作为父亲或母亲时，其子女出现先天性畸形也有可能与他们自身有关。我们运用姐妹染色单体交换（SCE）技术（一种灵敏的致突变性指标），观察了不同年龄组的男性和女性癫痫患者在抗惊厥治疗前后以及与对照组相比的致突变易感性。所有年龄组中，无论治疗与否，患者的SCE频率均显著高于对照组。在26 - 50岁年龄组中，未治疗患者的SCE频率显著高于接受治疗的患者（p < 0.01）。同样，未治疗的男性患者与接受治疗的男性患者相比，SCE频率显著更高（p < 0.025）。尽管本研究结果对癫痫患者的致突变性进行了总体评估，这与其他研究结果一致，并强调了该疾病在其后代先天性畸形发生率较高方面所起的作用，但未治疗患者中较高的SCE频率的重要性仍有待进一步研究来解释。
