用于饮料强化潜在应用的纳米脂质体维生素D3制剂。
Formulation of nanoliposomal vitamin d3 for potential application in beverage fortification.
作者信息
Mohammadi Maryam, Ghanbarzadeh Babak, Hamishehkar Hamed
机构信息
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ; Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
出版信息
Adv Pharm Bull. 2014 Dec;4(Suppl 2):569-75. doi: 10.5681/apb.2014.084. Epub 2014 Dec 31.
PURPOSE
Vitamin D, a liposoluble vitamin has many benefits on health. Encapsulation of bioactives in lipid-based carrier systems like nanoliposomes preserves their native properties against oxidation over time along with providing its stable aqueous dispersion.
METHODS
In the current study, vitamin D3 nanoliposomes were prepared using thin-film hydration-sonication method and fully characterized by different instrumental techniques.
RESULTS
According to FTIR and DSC results, no interaction was observed between encapsulated nutraceutical and liposome constituents. The particle size and size distribution (Span value) were calculated 82-90 nm and 0.70-0.85, respectively. TEM analysis showed nano sized globular and bilayer vesicles. In all formations, the encapsulation efficiency of vitamin D3 was calculated more than 93%. Addition of cholesterol to lecithin bilayer increased the negative zeta potential from -29 to -43mV.
CONCLUSION
The results of this study concluded that the liposomal nanoparticles may be introduced as a suitable carrier for fortification of beverages with vitamin D3.
目的
维生素D是一种脂溶性维生素，对健康有诸多益处。将生物活性物质包裹于脂质体等基于脂质的载体系统中，不仅能随时间推移保持其天然特性以防氧化，还能提供稳定的水分散体。
方法
在本研究中，采用薄膜水化-超声法制备维生素D3纳米脂质体，并通过不同仪器技术对其进行全面表征。
结果
根据傅里叶变换红外光谱（FTIR）和差示扫描量热法（DSC）结果，未观察到包封的营养保健品与脂质体成分之间存在相互作用。计算得出粒径和粒径分布（跨度值）分别为82 - 90纳米和0.70 - 0.85。透射电子显微镜（TEM）分析显示为纳米级球状和双层囊泡。在所有制剂中，维生素D3的包封效率计算得出超过93%。向卵磷脂双层中添加胆固醇使负zeta电位从 - 29mV增加到 - 43mV。
结论
本研究结果表明，脂质体纳米颗粒可作为一种合适的载体，用于在饮料中强化维生素D3。
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