Dalmoro Annalisa, Bochicchio Sabrina, Lamberti Gaetano, Bertoncin Paolo, Janssens Barbara, Barba Anna Angela
Eng4Life Srl, Spin-off Accademico Via Fiorentino, 32 83100 Avellino Italy.
Dipartimento di Farmacia, Università degli Studi di Salerno via Giovanni Paolo II, Fisciano 132 84084 SA Italy
RSC Adv. 2019 Jun 25;9(34):19800-19812. doi: 10.1039/c9ra03022k. eCollection 2019 Jun 19.
Micronutrients administration by fortification of staple and complementary foods is a followed strategy to fight malnutrition and micronutrient deficiencies and related pathologies. There is a great industrial interest in preparation of formulations for joint administration of vitamin D3 and vitamin K2 for providing bone support, promoting heart health and helping boost immunity. To respond to this topic, in this work, uncoated nanoliposomes loaded with vitamin D3 and K2 were successfully prepared, by using a novel, high-yield and semi continuous technique based on simil-microfluidic principles. By the same technique, to promote and to enhance mucoadhesiveness and stability of the produced liposomal structures, chitosan was tested as covering material. By this way polymer-lipid hybrid nanoparticles, encapsulating vitamin D3 and vitamin K2, with improved features in terms of stability, loading and mucoadhesiveness were produced for potential nutraceutical and pharmaceutical applications.
通过强化主食和辅食来补充微量营养素是对抗营养不良、微量营养素缺乏及相关病症的常用策略。在制备用于联合补充维生素D3和维生素K2的制剂方面，存在巨大的产业利益，这类制剂有助于骨骼健康、促进心脏健康并增强免疫力。为回应这一主题，在本研究中，基于类似微流控原理的新型、高产且半连续技术成功制备了负载维生素D3和K2的未包衣纳米脂质体。采用相同技术，以壳聚糖作为包衣材料进行测试，以促进和增强所制备脂质体结构的粘膜粘附性和稳定性。通过这种方式，制备出了包裹维生素D3和K2的聚合物-脂质杂化纳米颗粒，其在稳定性、载药量和粘膜粘附性方面具有改进特性，具有潜在的营养保健品和药物应用价值。
