Rosebush P, Stewart T
Department of Psychiatry, Beth Israel Hospital, Boston.
Am J Psychiatry. 1989 Jun;146(6):717-25. doi: 10.1176/ajp.146.6.717.
The authors prospectively studied 24 consecutive cases of neuroleptic malignant syndrome occurring in 20 patients in a general hospital over a 6-year period. They present detailed data concerning the clinical setting in which neuroleptic malignant syndrome occurs, the associated clinical and laboratory features, the favorable outcome that can be achieved with vigorous supportive therapy, and the factors that might help predict whether patients with neuroleptic malignant syndrome will subsequently be able to tolerate the reintroduction of neuroleptic medication.
作者前瞻性地研究了一家综合医院在6年期间20例患者中连续发生的24例抗精神病药恶性综合征。他们提供了有关抗精神病药恶性综合征发生的临床背景、相关临床和实验室特征、积极支持治疗可取得的良好结果，以及可能有助于预测抗精神病药恶性综合征患者随后是否能够耐受重新使用抗精神病药物的因素的详细数据。
