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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Ribera A B, Nastuk W L

Department of Physiology, Columbia University, New York, NY 10032.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;93(1):137-41. doi: 10.1016/0742-8413(89)90023-6.

The actions of the calcium channel blocker verapamil were studied at the neuromuscular junction of the frog Rana pipiens. 2. In the presence of 50 microM verapamil, subthreshold endplate potentials were produced, and the quantal content was reduced by a factor of 3. 3. Verapamil (10-50 microM) also reduced the postjunctional membrane sensitivity as measured by (a) carbachol iontophoresis and (b) miniature endplate potential amplitude. In addition, verapamil had a strong inhibitory effect on the postjunctional membrane response to repetitive iontophoretic application of carbachol. 4. Thus, verapamil has both pre- and postsynaptic actions at the neuromuscular junction.

在牛蛙的神经肌肉接头处研究了钙通道阻滞剂维拉帕米的作用。2. 在存在50微摩尔维拉帕米的情况下，产生了阈下终板电位，量子含量降低了3倍。3. 维拉帕米（10 - 50微摩尔）还降低了接头后膜的敏感性，这通过（a）卡巴胆碱离子透入法和（b）微小终板电位幅度来测量。此外，维拉帕米对接头后膜对重复离子透入应用卡巴胆碱的反应有强烈的抑制作用。4. 因此，维拉帕米在神经肌肉接头处具有突触前和突触后作用。

Ribera A B, Nastuk W L

Department of Physiology, Columbia University, New York, NY 10032.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;93(1):137-41. doi: 10.1016/0742-8413(89)90023-6.

The actions of the calcium channel blocker verapamil were studied at the neuromuscular junction of the frog Rana pipiens. 2. In the presence of 50 microM verapamil, subthreshold endplate potentials were produced, and the quantal content was reduced by a factor of 3. 3. Verapamil (10-50 microM) also reduced the postjunctional membrane sensitivity as measured by (a) carbachol iontophoresis and (b) miniature endplate potential amplitude. In addition, verapamil had a strong inhibitory effect on the postjunctional membrane response to repetitive iontophoretic application of carbachol. 4. Thus, verapamil has both pre- and postsynaptic actions at the neuromuscular junction.

在牛蛙的神经肌肉接头处研究了钙通道阻滞剂维拉帕米的作用。2. 在存在50微摩尔维拉帕米的情况下，产生了阈下终板电位，量子含量降低了3倍。3. 维拉帕米（10 - 50微摩尔）还降低了接头后膜的敏感性，这通过（a）卡巴胆碱离子透入法和（b）微小终板电位幅度来测量。此外，维拉帕米对接头后膜对重复离子透入应用卡巴胆碱的反应有强烈的抑制作用。4. 因此，维拉帕米在神经肌肉接头处具有突触前和突触后作用。